Research Areas

Multimodal functional brain imaging

This project combines near infrared spectroscopy (NIRS) with functional MRI (fMRI) to study brain function and hemodynamics non-invasively. The concurrent study has been used to validate several NIRS methods and has been a major factor in our efforts to develop more comfortable, adaptable NIRS probes. Recently, a novel method: Regressor Interpolation at Progressive Time Delays (RIPTiDe) was developed to use NIRS data recorded at superficial layer of the brain or peripheral sites (e.g. fingertip) to remove the physiological noise from fMRI BOLD signal, which leads to much accurate detection of resting state network.

Multimodal circulatory imaging

This project uses concurrent NIRS/fMRI or fMRI alone to dynamically map the cerebral blood circulation. The novel technique was first tested out on concurrent NIRS/fMRI data in resting state data. The goal of the project is to validate and quantify the method, and make it widely available to help people assess the cerebrovascular abnormities in many conditions. 

Real time optical imaging

The project is to develop effective protocol and tasks to establish real time neural feedback for subjects with drug abuse history using NIRS. The goal is to explore the possibility of using NIRS to monitor brain function to provide neural feedback for behavioral modification.

NIRS instrumentation development

We have a number of projects underway to develop new types of MR compatible NIRS probes, and to construct inexpensive NIRS spectrometers for peripheral hemodynamic measurements.